Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions

نویسندگان

  • Agnieszka Kudelko
  • Karolina Jasiak
  • Krzysztof Ejsmont
چکیده

ABSTRACT A series of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles were efficiently synthesized by cyclocondensation of the appropriate 3-(pyridyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid. The products were identified by means of spectroscopic methods and their pKA ionization constants were determined. The influence of substituents on the basicity of the pyridine system has been discussed. GRAPHICAL ABSTRACT

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عنوان ژورنال:

دوره 146  شماره 

صفحات  -

تاریخ انتشار 2015